1-Adamantanamine hydrochloride
1-Adamantanamine hydrochloride
CAS: 665-66-7
Molecular Formula: C10H18ClN
1-Adamantanamine hydrochloride - Names and Identifiers
| Name | 1-Adamantanamine hydrochloride |
| Synonyms | AMANTADINE HCL Amantadine hydrochloride 1-Amantadine hydrochloride 1-Adamantamine hydrochloride 1-Adamantanamine hydrochloride 1-Adamantanamine Hydrochleride 1-Aminoadamantane hydrochloride 1-Adamantylamine Hydrochloride 1-adamantane amine hydrochloride Amantadine Hydrochloride (200 mg) tricyclo[3.3.1.1~3,7~]decan-1-aminium (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine 1-Aminoadamantane HydrochlorideAmantadine Hydrochloride Amantadine hydrochloride,1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride |
| CAS | 665-66-7 |
| EINECS | 211-560-2 |
| InChI | InChI=1/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2/t7-,8+,9-,10- |
| InChIKey | WOLHOYHSEKDWQH-UHFFFAOYSA-N |
1-Adamantanamine hydrochloride - Physico-chemical Properties
| Molecular Formula | C10H18ClN |
| Molar Mass | 187.71 |
| Density | 1.0276 (rough estimate) |
| Melting Point | >300°C(lit.) |
| Boling Point | 308.63°C (rough estimate) |
| Flash Point | 95.974°C |
| Water Solubility | soluble |
| Solubility | H2O: 50mg/mL |
| Vapor Presure | 0.085mmHg at 25°C |
| Appearance | White crystal |
| Color | White |
| Merck | 14,374 |
| BRN | 4198854 |
| Storage Condition | Store below +30°C. |
| Sensitive | Hygroscopic |
| Refractive Index | 1.6100 (estimate) |
| MDL | MFCD00074723 |
| Physical and Chemical Properties | Melting point 300°C water-soluble soluble |
| Use | Used as an antiviral drug |
1-Adamantanamine hydrochloride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R40 - Limited evidence of a carcinogenic effect R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S36 - Wear suitable protective clothing. S35 - This material and its container must be disposed of in a safe way. S20/21 - |
| UN IDs | UN 1759 8 / PGII |
| WGK Germany | 3 |
| RTECS | AU4375000 |
| TSCA | Yes |
| HS Code | 29213000 |
| Hazard Class | IRRITANT |
| Toxicity | LD50 orally in mice, rats: 700, 1275 mg/kg (Vernier) |
1-Adamantanamine hydrochloride - Upstream Downstream Industry
| Raw Materials | Dicyclopentadiene Aluminum-nickel catalyst Chlorine Urea Hydrogen Aluminum chloride Bromine Sodium sulfite Hydrochloric acid |
1-Adamantanamine hydrochloride - Standard
Authoritative Data Verified Data
This product is tricyclic [3. 3. 1. 13 '7] decane -1-amine hydrochloride. The content of C10H17N • HCl shall not be less than 99.0% calculated on a dry basis.
Last Update：2024-01-02 23:10:35
1-Adamantanamine hydrochloride - Trait
Authoritative Data Verified Data
- This product is white crystal or crystalline powder; Odorless.
- This product is soluble in water or ethanol, dissolved in chloroform.
Last Update：2022-01-01 15:06:34
1-Adamantanamine hydrochloride - Introduction
Soluble in water, slightly soluble in ethanol, very slightly soluble in acetone, insoluble in benzene and ether. No smell, bitter taste.
Last Update：2022-10-16 17:27:48
1-Adamantanamine hydrochloride - Differential diagnosis
Authoritative Data Verified Data
- Take 10mg of this product, add 2ml of water to dissolve, add hydrochloric acid to make it acidic, and add silicotungstic acid solution Dropwise to precipitate white precipitate.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 369).
- the aqueous solution of this product can identify the reaction of (1) (General rule 0301).
Last Update：2022-01-01 15:06:35
1-Adamantanamine hydrochloride - Exam
Authoritative Data Verified Data
acidity
take 2.0g of this product, Add 10ml of water to dissolve, and measure according to law (General rule 0631). The pH value should be 3.5~5.0.
clarity and color of solution
take this product l. After adding 10ml of water to dissolve, the solution should be clear and colorless; If it is turbid, it should not be more concentrated compared with No. 1 turbidity standard solution (General rule 0902 first method); If it is colored, comparison with yellow No. 2 Standard Colorimetric solution (General rule 0901 first method), not deeper.
Related substances
take this product about l. Add 5mol/L sodium hydroxide solution (20ml) and trichloromethane (18ml) to the separating funnel, shake for 10 minutes, let stand and separate into layers, take the three-gas methane layer, shake and dehydrate with appropriate amount of anhydrous sodium sulfate, and filter, take the filtrate and put it in a 20ml measuring flask, dilute it to the scale with chloroform, and shake it up to be used as a test solution. Take about 0.5g of the adamantane reference substance, put it in a 10ml measuring flask, dissolve it with three gases of methane and dilute it to the scale, shake it well, take 1ml of the solution, put it in a ml measuring flask, and add 1ml of the test solution, dilute to the scale with chloroform and shake well as a system-suitable solution. According to the gas chromatography method (General 0521) test, the capillary column with 5% phenyl-95% methyl polysiloxane (or similar polarity) as the stationary liquid is used as the column; The initial temperature is 70°C, and the maintenance time is 5 minutes, the temperature was raised to 250°C at a rate of 10°C per minute for 17 minutes; The inlet temperature was 220°C; And the detector temperature was 300°C. Take the system applicable solution 2 u1 and inject it into the gas chromatograph. The separation degree of amantadine peak and adamantane peak should be greater than 20, and the signal-to-noise ratio of amantadine peak height should be greater than 30. The sample solution 2u1 was accurately measured and injected into human gas chromatograph, and the chromatogram was recorded. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be more than 0.3% of the total peak area, and the sum of each impurity peak area shall not be more than 1.0% of the total peak area, calculated by the normalization method.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Heavy metals
take 2.0g of this product, add 23ml of water to dissolve, add 2ml of acetate buffer (pH 3.5), and check according to law (General rule 0821 first law), containing heavy metals not more than 5 parts per million.
Last Update：2022-01-01 15:06:36
1-Adamantanamine hydrochloride - Content determination
Authoritative Data Verified Data
take this product about 0.15g, precision weighing, plus O.Olmol/L hydrochloric acid solution 5ml and ethanol 50ml to dissolve, according to the potentiometric titration method (General 0701), with sodium hydroxide titration solution (0.1 mol/L) titration, the difference between the two burst point volumes as The titration volume. Each 1 ml of sodium hydroxide titration solution (0.1 mol/L) corresponds to 18.77mg of C10H17N. Hc1.
Last Update：2022-01-01 15:06:36
1-Adamantanamine hydrochloride - Category
Authoritative Data Verified Data
Anti-Parkinson's disease drugs, antiviral drugs.
Last Update：2022-01-01 15:06:36
1-Adamantanamine hydrochloride - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 15:06:36
1-Adamantanamine hydrochloride - Amantadine hydrochloride tablets
Authoritative Data Verified Data
This product contains amantadine hydrochloride (C10H17N • HCI) should be 93.0% ~ 107.0% of the label amount.
trait
This product is white tablet.
identification
- take an appropriate amount of fine powder of this product (equivalent to amantadine hydrochloride 0.lg), add 5ml of water, shake, filter, and filter the filtrate according to the identification (1) and (3) tests under amantadine hydrochloride, the same reaction was shown.
- take an appropriate amount of the fine powder of this product (about 0.2g equivalent to amantadine hydrochloride), add 50ml of dichloromethane, shake to dissolve amantadine hydrochloride, filter, and evaporate the filtrate to dryness in a water bath, the residue shall be determined according to law (General rule 0402), and the infrared absorption spectrum of this product shall be consistent with the spectrum of the control (Spectrum set 369).
examination
should be in accordance with the relevant provisions under The tablet item (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing appropriate amount (about 0.3g equivalent to amantadine hydrochloride), put it in a plug Erlenmeyer flask, Precision Add 50ml of ethanol, shake for 20 minutes to dissolve amantadine hydrochloride, filter with dry filter paper, take 20ml of continued filtrate accurately, add 5ml of 0.01mol/L hydrochloric acid solution and about 30ml of ethanol, potentiometric titration (General 0701), with sodium hydroxide titration solution (0.1mol/L) titration, the difference between the two burst point volumes as The titration volume. Each 1 ml of sodium hydroxide titration solution (0.1 mol/L) corresponds to 18.77mg of C10H17N. Hc1.
category
Same as amantadine hydrochloride.
specification
O.lg
storage
light shielding, sealed storage.
Last Update：2022-01-01 15:06:37
1-Adamantanamine hydrochloride - Amantadine hydrochloride capsules
Authoritative Data Verified Data
This product contains amantadine hydrochloride (Cl0H17N • HCI) should be 93.0% ~ 107.0% of the label amount.
identification
- take an appropriate amount of the content of this product (about 0.1g equivalent to amantadine hydrochloride), add 5ml of water, shake to dissolve amantadine hydrochloride, filter, take the filtrate under amantadine hydrochloride identification (1), (3) one trial showed the same response.
- take an appropriate amount of the fine powder of this product (about 0.2g equivalent to amantadine hydrochloride), add 50ml of dichloromethane, shake to dissolve amantadine hydrochloride, filter, dry the filtrate in a water bath, and take the residue, according to the determination (General Principles 0402), the infrared absorption spectrum of this product should be consistent with the control spectrum (Spectrum set 369 figure).
examination
should comply with the relevant provisions under the capsule (General rule 0103).
inclusion assay
take the contents under the difference of loading amount, mix them evenly, weigh an appropriate amount (about 0.3g equivalent to amantadine hydrochloride) precisely, put them in a plug Erlenmeyer flask, and add 50ml of ethanol precisely, shake for 20 minutes to dissolve amantadine hydrochloride, filter with dry filter paper, take 20ml of continued filtrate accurately, add 5ml of 0.01mol/L hydrochloric acid solution and about 30ml of ethanol, potentiometric titration (General 0701), with sodium hydroxide titration solution (0.1mol/L) titration, the difference between the two burst point volumes as The titration volume. Each 1 ml of sodium hydroxide titration solution (0.1 mol/L) corresponds to 18.77mg of C10H17N. Hc1.
category
Same as amantadine hydrochloride.
specification
O.lg
storage
light shielding, sealed storage.
Last Update：2022-01-01 15:06:38
1-Adamantanamine hydrochloride - Amantadine Hydrochloride Granules
Authoritative Data Verified Data
This product contains amantadine hydrochloride (C10H17N • HCl) should be 93.0% to 107.0% of the label.
trait
This product is white particles.
identification
- take an appropriate amount of this product (approximately equivalent to amantadine hydrochloride O.lg), 5ml of water was added, amantadine hydrochloride was dissolved by shaking, filtered, and the filtrate was taken to show the same reaction according to the identification tests (1) and (3) of amantadine hydrochloride.
- take an appropriate amount of the fine powder of this product (about 0.2g equivalent to amantadine hydrochloride), add 50ml of dichloromethane, shake to dissolve amantadine hydrochloride, filter, dry the filtrate in a water bath, and take the residue, according to the determination (General Principles 0402), the infrared absorption spectrum of this product should be consistent with the control spectrum (Spectrum set 369 figure).
examination
should be consistent with the granules under the relevant provisions (General Principles 0104).
Content determination
Take 20 bags of this product, precision weighing, calculate the average loading. Take the contents, mix well, grind finely, weigh properly (about 0.3g equivalent to amantadine hydrochloride), place them in a plug Erlenmeyer flask, add accurately 50ml of ethanol, and shake for 20 minutes to dissolve amantadine hydrochloride, filter with dry filter paper, take 20ml of continued filtrate with precision, add 0.Olmol/L hydrochloric acid solution 5ml and ethanol about 30ml, according to the potentiometric titration method (General 0701), with sodium hydroxide titration solution (0.1 mol/L) titration, the difference between the two burst point volumes as The titration volume. Each 1 ml of sodium hydroxide titration solution (0.1 mol/L) corresponds to 18.77mg of C10H17N-HCl.
category
Same as amantadine hydrochloride.
specification
(l)6g:60mg (2)12g:140mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 15:06:39
1-Adamantanamine hydrochloride - Amantadine hydrochloride syrup
Authoritative Data Verified Data
This product contains amantadine hydrochloride (Cl0H17N • HCl) should be 93.0% ~ 107.0% of the label amount.
trait
This product is colored clear viscous liquid.
identification
take 5ml of this product, add 1ml of 20% sodium hydroxide solution, shake well, add 5ml of ethyl acetate, shake, and let stand for standing. After stratification, take ethyl acetate layer, add 5ml of lmol/L hydrochloric acid solution, after shaking and standing, 2ml of the aqueous layer was collected, and a silicotungstic acid test solution was added dropwise to form a white precipitate.
examination
- the pH value should be 3.0 to 4.0 (General 0631).
- relative density the relative density of this product (General 0601) should not be less than 1.240.
- others shall comply with the relevant provisions under syrup (General rule 0116).
Content determination
take 50ml of this product (about 250mg equivalent to amantadine hydrochloride) with a volume pipette and place it in a separatory funnel. Wash the inner wall of the pipette with a small amount of water and wash it in the separatory funnel, then add 13ml of 20% sodium hydroxide solution, shake well, add 40ml of ethyl acetate precisely, shake for 15 minutes, stand still, separate layers, and take 20ml of ethyl acetate layer precisely, put in an Erlenmeyer flask containing 50ml of glacial acetic acid in advance, add 2 drops of crystal violet indicator solution, and use high-gas acid titration solution (0.1 mol/L) titration to the solution changed from purple to blue, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 18.77mg of C10H17N. HCl.
category
Same as amantadine hydrochloride.
specification
(l)10ml (2) 60ml (3) 100ml (4) 120ml(5)500ml
storage
light shielding, closed storage.
Last Update：2022-01-01 15:06:40
1-Adamantanamine hydrochloride - Reference Information
| LogP | -1.64 at 23℃ and pH6.3 |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | Anti-Virus drug, belonging to narrow spectrum, is only used for the prevention and treatment of influenza caused by type A2 Virus. The product prevents Virus of the penetration into the host cell, and affects Virus of the shell, to inhibit Virus of the proliferation. This product is used as an anti-paralysis drug. May promote dopamine release. amantadine hydrochloride is used as an antiviral agent; The product is used as an anti-paralytic agent. May promote dopamine release. for the synthesis of anti-Virus drug intermediate, which has the effect of preventing and treating type A2 influenza This product prevents Virus from penetrating into host cells and affects Virus of The unshelled, virus inhibition of proliferation. May promote dopamine release. Virus was prevented from penetrating into the host cell, and Virus was affected to decoat, and Virus proliferation was inhibited. May promote dopamine release. |
| production method | It is obtained by salt formation and purification of amantadine. Amantadine, distilled water and activated carbon were added to the glass enamel. Hydrochloric acid was added to adjust the pH to 3-5, heated to 70 °c for half an hour to dissolve the decolorizing, cooled to room temperature, and filtered. The filtrate was pumped into a reduced-pressure concentration tank, concentrated in (14.7kPa) to the shape of a porridge, naturally cooled, and filtered. Acetone was added to soak and rinse to pH 5, filtered and dried at 70 ° C. To obtain amantadine hydrochloride. |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 800 mg/kg; Oral-mouse LD50: 700 mg/kg |
| flammability hazard characteristics | toxic nitrogen oxides and hydrogen chloride smoke produced by combustion; Food: Fantasy, elation, excitement, dream |
| storage and transportation characteristics | ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
Last Update：2024-04-09 15:16:52
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Product Name: 1-Adamantanamine hydrochloride Request for quotation
CAS: 665-66-7
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Mobile: 0086 189 4982 3763
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CAS: 665-66-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
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Mobile: 0086 189 4982 3763
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Wechat: 0086 189 4982 3763
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Product Name: Amantadine hydrochloride Visit Supplier Webpage Request for quotationCAS: 665-66-7
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View History
Raw Materials for 1-Adamantanamine hydrochloride